Klinikai vizsgálatok

DISCHARGE

This is a pragmatic randomised controlled trial (PRCT) evaluating the superiority of CT over ICA concerning effectiveness in stable chest pain patients with intermediate pretest probability of coronary artery disease.

Disease: Coronary artery disease

ECRIN support role: Monitoring

Study/trial status: Recruitment/follow-up

Actual trial start date: 01/10/2015

Expected patient number: 3546 patients

Sponsor: Charite/Universitätsmedizin Berlin, Germany

Sponsor type: Academic

Principal investigator (PI): Marc Dewey

Current participating countries: Austria, Belgium, Czech Republic, Denmark, Finland, France, Germany, Hungary, Ireland, Italy, Latvia, Lithuania, Netherlands, Portugal, Romania, Serbia, Spain, United Kingdom

Trial identifier(s): NCT NCT02400229
 

EUROHYP-1

The purpose of this study is to determine if systemic cooling to a target temperature of 34 to 35°C, started within six hours of symptom onset and maintained for 24 hours, improves functional outcome at three months in patients with acute ischaemic stroke.

Disease: Acute ischaemic stroke

Study phase: III

ECRIN support role: Monitoring

Study/trial status: Recruitment/follow-up

Expected patient number: 800 patients

Sponsor: University of Erlangen-Nurnberg Medical School

Sponsor type: Academic

Principal investigator (PI): Stefan Schwab

Current participating countries: Belgium, Bulgaria, Croatia, Czech Republic, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, Netherlands, Norway, Poland, Romania, Spain, Sweden, Turkey, United Kingdom

Trial identifier(s): NCT NCT01833312

 

IMPACTT

The purpose of this study is to prolong the time to reinfection with Pseudomonas aeruginosa after successfully treated acute or intermittent infection.

Disease: Cystic fibrosis

Study phase: III

ECRIN support role: Advice and information

Monitoring

Local pharmacovigilance

Regulatory and ethical submission

Study/trial status: Recruitment/follow-up

Expected patient number: 180 patients

Sponsor: Mukoviszidose Institut gGmbH

Sponsor type: Academic

Principal investigator (PI): Antje Schuster

Current participating countries: Austria, Belgium, France, Germany, Hungary, Italy, Poland, Spain, Sweden

Trial identifier(s): NCT NCT01455675

EudraCT 2011-000801-39

PRECIOUS

Elderly patients have a high risk of complications after stroke, such as infections or fever. This study aims to assess whether preventive treatment in the first four days of hospitalisation with ceftriaxone, paracetamol, and/or metoclopramide prevents the most common complications and reduce the risk of death or long-term disability compared to standard care alone.

Disease: Stroke

Study phase: III

ECRIN support role: Monitoring

Funding application support

Study/trial status: Recruitment/follow-up

Actual trial start date: 01/03/2016

Expected patient number: 3800 patients

Sponsor: Universitair Medisch Centrum Utrecht

Sponsor type: Academic

Principal investigator (PI): Bart van der Worp

Current participating countries: Estonia, France, Germany, Hungary, Italy, Netherlands, Norway, Poland, United Kingdom

 

SECURE

The purpose of this study is to evaluate the efficacy of a polypill strategy containing aspirin (100 mg), ramipril (2.5, 5 or 10 mgs), and atorvastatin (40 mgs) compared with the standard of care (usual care according to the local clinical practices at each participating country) in secondary prevention of major cardiovascular events (cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, and urgent revascularization) in elderly patients with a recent myocardial infarction.

Disease: Cardiovascular disease

Study phase: III

ECRIN support role: Local pharmacovigilance

Study/trial status: Start-up phase

Actual trial start date: 17/05/2016

Expected patient number: 3206 patients

Sponsor: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)

Sponsor type: Academic

Principal investigator (PI): Valentín Fuster

Current participating countries: