Clinical Trials
This is a pragmatic randomised controlled trial (PRCT) evaluating the superiority of CT over ICA concerning effectiveness in stable chest pain patients with intermediate pretest probability of coronary artery disease.
Disease: Coronary artery disease
ECRIN support role: Monitoring
Study/trial status: Recruitment/follow-up
Actual trial start date: 01/10/2015
Expected patient number: 3546 patients
Sponsor: Charite/Universitätsmedizin Berlin, Germany
Sponsor type: Academic
Principal investigator (PI): Marc Dewey
Current participating countries: Austria, Belgium, Czech Republic, Denmark, Finland, France, Germany, Hungary, Ireland, Italy, Latvia, Lithuania, Netherlands, Portugal, Romania, Serbia, Spain, United Kingdom
Trial identifier(s): NCT NCT02400229
The purpose of this study is to determine if systemic cooling to a target temperature of 34 to 35°C, started within six hours of symptom onset and maintained for 24 hours, improves functional outcome at three months in patients with acute ischaemic stroke.
Disease: Acute ischaemic stroke
Study phase: III
ECRIN support role: Monitoring
Study/trial status: Recruitment/follow-up
Expected patient number: 800 patients
Sponsor: University of Erlangen-Nurnberg Medical School
Sponsor type: Academic
Principal investigator (PI): Stefan Schwab
Current participating countries: Belgium, Bulgaria, Croatia, Czech Republic, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, Netherlands, Norway, Poland, Romania, Spain, Sweden, Turkey, United Kingdom
Trial identifier(s): NCT NCT01833312
The purpose of this study is to prolong the time to reinfection with Pseudomonas aeruginosa after successfully treated acute or intermittent infection.
Disease: Cystic fibrosis
Study phase: III
ECRIN support role: Advice and information
Monitoring
Local pharmacovigilance
Regulatory and ethical submission
Study/trial status: Recruitment/follow-up
Expected patient number: 180 patients
Sponsor: Mukoviszidose Institut gGmbH
Sponsor type: Academic
Principal investigator (PI): Antje Schuster
Current participating countries: Austria, Belgium, France, Germany, Hungary, Italy, Poland, Spain, Sweden
Trial identifier(s): NCT NCT01455675
EudraCT 2011-000801-39
Elderly patients have a high risk of complications after stroke, such as infections or fever. This study aims to assess whether preventive treatment in the first four days of hospitalisation with ceftriaxone, paracetamol, and/or metoclopramide prevents the most common complications and reduce the risk of death or long-term disability compared to standard care alone.
Disease: Stroke
Study phase: III
ECRIN support role: Monitoring
Funding application support
Study/trial status: Recruitment/follow-up
Actual trial start date: 01/03/2016
Expected patient number: 3800 patients
Sponsor: Universitair Medisch Centrum Utrecht
Sponsor type: Academic
Principal investigator (PI): Bart van der Worp
Current participating countries: Estonia, France, Germany, Hungary, Italy, Netherlands, Norway, Poland, United Kingdom
The purpose of this study is to evaluate the efficacy of a polypill strategy containing aspirin (100 mg), ramipril (2.5, 5 or 10 mgs), and atorvastatin (40 mgs) compared with the standard of care (usual care according to the local clinical practices at each participating country) in secondary prevention of major cardiovascular events (cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, and urgent revascularization) in elderly patients with a recent myocardial infarction.
Disease: Cardiovascular disease
Study phase: III
ECRIN support role: Local pharmacovigilance
Study/trial status: Start-up phase
Actual trial start date: 17/05/2016
Expected patient number: 3206 patients
Sponsor: Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Sponsor type: Academic
Principal investigator (PI): Valentín Fuster
Current participating countries: