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The purpose of this study is to determine if systemic cooling to a target temperature of 34 to 35°C, started within six hours of symptom onset and maintained for 24 hours, improves functional outcome at three months in patients with acute ischaemic stroke.

Disease: Acute ischaemic stroke

Study phase: III

ECRIN support role: Monitoring

Study/trial status: Recruitment/follow-up

Expected patient number: 800 patients

Sponsor: University of Erlangen-Nurnberg Medical School

Sponsor type: Academic

Principal investigator (PI): Stefan Schwab

Current participating countries: Belgium, Bulgaria, Croatia, Czech Republic, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, Netherlands, Norway, Poland, Romania, Spain, Sweden, Turkey, United Kingdom

Trial identifier(s): NCT NCT01833312